Temporary

Part:BBa_K3833001

Designed by: Margaret Keymakh, Deniz Sinar   Group: iGEM21_Cornell   (2021-10-01)


Integrin Binding Domain (GLPGER)

Integrins are transmembrane receptors that allow for cell adhesion to a cell's extracellular matrix. Integrin recognition sequences can form a basis for binding domains within proteins [1]. The documented part is meant for insertion into the triple helical structure of Scl2 (Part BBa_K3833000) in order to allow for cell adhesion to hydrogels containing the protein. This part contains the integrin binding domain GLPGER.


Sources:
[1] Seo, N., Russell, B. H., Rivera, J. J., Liang, X., Xu, X., Afshar-Kharghan, V., & Höök, M. (2010). An engineered α1 integrin-binding collagenous sequence. Journal of Biological Chemistry, 285(40), 31046-31054.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None